Stem cell therapy in pulmonary fibrosis pdf

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Front Med. Curr Stem Cell Res Ther. Expert opinion: After many years of investigation, the use of cell-based therapies to treat IPF is still at the experimental phase. Problems include bioethical issues, safety of cell transplantation, routes of delivery and the dose and timing of administration.

Further investigations are necessary to establish the best strategy for using cell-based therapies effectively for the treatment of IPF. Results: Preliminary results recently presented in the form of an abstract seem promising and tantalizing since there were no cases of clinically significant allergic reactions, infections, disease acute exacerbations or ectopic tissue formation.

In addition 6 months follow-up data revealed a marginal improvement at 6-minute walking distance and forced vital capacity. Conclusions: Adipose tissue represents an abundant, safe, ethically uncontested and potentially beneficial source of stem cells for patients with IPF.

Larger multicenter phase II and III placebo-controlled clinical trials are sorely needed in order to prove efficacy.