There are many subtypes of this type of tumor. This summary is about exocrine pancreatic cancer. Further mention of pancreatic cancer refers only to pancreatic adenocarcinoma, and not pancreatic NETs. Anything that increases your chance of developing pancreatic cancer is a risk factor. Some risk factors can be changed, while others cannot. Not everyone with the above risk factors gets pancreatic cancer. However, if you have risk factors, you should discuss them with your doctor.
Though the disease has not spread, these cases are treated with complicated surgical operations that require a high level of experience to perform safely and effectively. At MD Anderson, you are the focus of a personalized pancreatic cancer treatment plan that brings together a multidisciplinary team of some of the top pancreatic cancer professionals that use the most advanced techniques.
When pancreatic cancer is confined to the pancreas, and sometimes when it has spread only to the nearby areas, it can be removed with surgery. The highest chances for successful treatment occur when the tumor is completely removed, and the surgical techniques required are extremely complex.
Because our surgeons are among the most experienced and skilled in the nation, MD Anderson has:. Our experts provide comprehensive pancreatic cancer care, and they have pioneered several advances in the field, including:. MD Anderson conducts a wide range of clinical trials to test new and innovative treatment options for both localized and metastatic pancreatic cancer.
The treatment options used in these trials often cannot be found anywhere else and are critical for advancing pancreatic cancer treatment. Learn more about our pancreatic cancer clinical trials and research. Radiation therapy can be a powerful tool in pancreatic cancer treatment. Our radiation oncologists are experts at stereotactic body radiation therapy SBRT and dose-escalation, which allow high doses of radiation to be delivered to the tumor without damaging healthy tissue.
Many MD Anderson faculty have led or are leading national clinical trials to improve radiation therapy for pancreatic cancer. MD Anderson patients have access to clinical trials offering promising new treatments that cannot be found anywhere else. Find the latest news and information about pancreatic cancer in our Knowledge Center, including blog posts, articles, videos, news releases and more.
My Chart. Donate Today. As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. Choose from 12 allied health programs at School of Health Professions.
Learn about our graduate medical education residency and fellowship opportunities. The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. While follicular lymphoma FL , a type of non-Hodgkin lymphoma , is usually slow-growing, most patients relapse, and it is rarely curable.
A research team led by Nathan Fowler, M. The therapy was well tolerated by the majority of patients, with mild to moderate cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome ICANS and neurological events, and no treatment-related deaths. These results suggest that tisagenlecleucel is a safe and effective option for treating patients with relapsed or refractory FL, including patients who have high-risk or advanced disease characteristics.
Learn more in Nature Medicine. Erdafitinib shows consistent results in follow-up of patients with urothelial cancer and FGFR mutations. In the primary analysis, published in , research led by Arlene Siefker-Radtke, M. Those results led to approval of erdafitinib by the Food and Drug Administration, making it the first oral targeted therapy approved for advanced bladder cancer. Treatment benefit with erdafitinib was observed in patients regardless of previous chemotherapy or immunotherapy, and there were no new safety signals.
Erdafitinib is currently being studied in other treatment settings. Learn more in Lancet Oncology. Unfortunately, no effective targeted therapies are available to treat patients with RNF43 mutations. Using a genetically engineered mouse model, researchers led by Abdel Nasser Hosein, M. They discovered that RNF43 acts as a tumor suppressor and its deletion cooperates with mutant KRAS to accelerate the development pre-cancerous lesions and pancreatic cancers.
Additionally, RNF43 loss resulted in a distinct tumor immune microenvironment marked by increased numbers of anti-tumor lymphocytes and fewer suppressive myeloid cells, suggesting these tumors may be susceptible to immune checkpoint inhibitors.
The B-Cell Lymphoma Moon Shot is revolutionizing the conventional medical research approach to rapidly translate findings into patient treatment options and develop personalized therapeutic strategies. To determine if patients are eligible for a pancreatic cancer clinical trial, the disease must be properly staged with a specialized CT scan triphasic CT or pancreas protocol CT. This usually requires a discussion with a multidisciplinary tumor board.
The current pancreatic cancer clinical trials are listed below. Find more information on clinical trials at MD Anderson. Patients are randomized to receive standard of care chemotherapy or definitive local therapy can be radiation, surgery, radiofrequency ablation, or a combination thereof followed by standard of care chemotherapy. Through the careful study and evaluation of new treatments and therapies, clinical trials help uncover better ways to prevent, diagnose and treat cancer.
Clinical trials can be a long, careful process. Often, they include many phases and last for many years. Clinical trials may be conducted for any type of cancer, but the cancers most commonly studied are:. At Banner MD Anderson Cancer Center, eligible patients may be given the opportunity to participate in select research studies to help evaluate the safety and efficacy of new treatments and increase understanding of the ways to fight cancer.
By conducting independent cancer clinical trials as well as collaborating with physicians from MD Anderson Cancer Center and other research institutions recognized nationally and worldwide, our patients have access to some of the latest and most advanced trials.
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